DESPITE/IN SPITE OF
These are preposition which can be used interchangeably. They mean the same as although, etc.; however, the grammar is different. They can got at the beginning or in the middle of a sentence.
Despite his physical handicap, he has become a successful businessman.
In spite of his physical handicap, he has become a successful businessman.
Jane will be admitted to the university despite her bad grades.
Jane will be admitted to the university in spite of her bad grades.
ALTHOUGH/ EVEN THOUGH/ THOUGH
These are subordinate conjuctions used to connect two clauses. Notice how grammar is different from that of despite and in spite of.
Although he has a physical handicap, he has become a successful businessman.
Jane will be admitted to the university even though she has bad grades.
In spite of the bad weather, we are going to have a picnic.
Although the weather was very bad, we had a picnic.
Note:
Despite his physical handicap, he has become a successful businessman. (Now, he is a successful businessman). This is an example of Present Perfect Tense.
In spite of the bad weather, we are going to have a picnic. (going to is related with plan. The sentence will use going to if the subject has a plan). If the subject has not a plan, the sentence will use “probably” or “will”)
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